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. 2012 Feb 16;7(2):e31721. doi: 10.1371/journal.pone.0031721

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Xu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Haematoxylin/eosin (H&E) staining of paraffin sections of splenic tissues from the Jak3^+/+ and Jak3^−/− mice intratracheally administered with PBS or HA for 72 h. Arrows show the necrosis of lymphocytes. (B) The cytokines/chemokines (IFN-γ, IP-10, MCP-1α and RANTES) that were released from the splenocytes of either Jak3^+/+ or Jak3^−/− mice pretreated with HA or PBS as described above. The measurement of the concentration of the cytokines/chemokines by Liquidchip assay. *P<0.05 vs. Jak3^+/+ PBS group; ^# P<0.05 vs. Jak3^+/+ HA group.