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. 2012 Feb 16;7(2):e31771. doi: 10.1371/journal.pone.0031771

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Yu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) PECAM immunostaining (black arrows) on PBS- (top) and ZA-treated (bottom) tibial (left) and mandibular (right) fracture calluses. Scale bar = 200 µm. (B) Analysis of the length density of blood vessels within the callus (mm/mm³) and (C) analysis of the surface density of blood vessels within the callus (mm²/mm³) in PBS- and zoledronate-treated mice at day 5 post-fracture (n = 6 per group). *p<0.05. Bars represent mean±s.d.