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. 2012 Feb 16;7(2):e29942. doi: 10.1371/journal.pone.0029942

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Gauglitz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fourteen cytokines secreted by keratinocytes and measured in this study were significantly altered in keratinocytes cultures from sites of burn injury. Particularly levels of IL-2, -4, IL-6, -10, IFN-γ, TGF-β1 and TNFα were significantly altered in response to burn injury as compared to controls. Histograms depict culture media concentrations of the respective cytokine at the time of analysis. Bars represent means; error bars correspond to SEM. Asterisks denote statistical difference between cultures from burned skin vs. control skin. (* p<0.05).