Table 1. Outcome measures between BM-MSC treatment groups and control groups.
BM-MSCs | HBSS alone | Dermalfibroblasts | DeadBM-MSCs | No treatment | Significance (p) | |
Median day of disease onset (range) | 12 (10–16) | 12 (10–13) | 12 (9–13) | 12.5 (10–14) | 12 (10–13) | 0.76* |
Median peak motor score (range) | 5.5 (4–7) | 5.5 (4–7) | 5 (4–6) | 5 (4–6) | 6 (4–9) | 0.3* |
Median terminal motor score (range) | 3 (0–5) | 3 (0–4) | 3.5 (2–5) | 2 (0–5) | 4 (2–6) | 0.41* |
Mean cumulative motor score (SD) | 65.3 (18) | 64.3 (17.6) | 69.6 (13.3) | 64.9 (21.9) | 76.9 (12.4) | 0.7§ |
Electrophysiology: ankle-foot median response score (range) | 2/1 (0–4)/(0–4) | 1/2 (0–3)/(0–4) | 1/2 (0–3)/(0–4) | 2/2 (0–4)/(0–2) | 0/2 (0–2)/(0–3) | 0.88* |
Mean count of ED1+ cells per HPF (SD) | 194 (81) | 192 (68) | 199 (84) | 204 (86) | 238 (63) | 0.71§ |
Mean % of myelinated axons per HPF (SD) | 25 (27) | 27 (20) | 27 (22) | 31 (24) | 9 (5) | 0.34§ |
SD – standard deviation;
Kruskal-Wallis test;
one way ANOVA, Tukey post-test;
HPF – high power field;