Table 1. Representive genes that were differentially expressed in the hippocampus and cortex of the aged rats after curcumin treatment.

Tissue	Treatment duration	Functional classification	Gene	Accession number	Fold change
Hippocampus	6-week	Neurotransmission/Synaptic function	Syt9	NM_053324	1.58
Cortex			Stx1a	NM_053788	1.87
			Cplx3	NM_001109295	1.62
		Transcription	Fezf2	NM_001107251	1.85
			Neurod1	NM_019218	2.3
			Neurod6	NM_001109237	1.86
Hippocampus	12-week	Signal transduction	Adcy1	NM_001107239	1.76
			Kit	NM_022264	0.61
			Htr2c	NM_012765	0.52
		Metabolism	Lpl	NM_012598	0.51
		Development	Wnt2	ENSRNOT00000010427	1.90
			Nnat	NM_053601	0.53
Cortex		Signal transduction	Tiam1	ENSRNOT00000046486	1.61
			Unc5d	NM_001107319	1.87
			Shank3	NM_021676	1.59
			Htr2a	NM_017254	0.33
		Neurotransmission/
Synaptic function	Nlgn2	NM_053992	1.76
			Cip98	NM_181088	1.55
		Immune response	Cd74	NM_013069	7
		Cell adhesion	Snip	NM_019378	1.64
		Cell cycle	Wee1	NM_001012742	0.63
		Calcium signing	Cav1	NM_031556	0.55