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. 2012 Feb 16;7(2):e31167. doi: 10.1371/journal.pone.0031167

Figure 1. Morphine enhances HIV Bal strain (A) and SIV DeltaB670 strain (B) infection of macrophages.

Figure 1

Seven-day-cultured macrophages were incubated with or without morphine (10−10 M) for 24 h before HIV or SIV infection. An opioid receptor antagonist, naltrexone (10−8 M) was added to macrophage cultures 1 h before morphine (10−10 M) treatment. HIV or SIV RT activity in culture supernatant was determined at day 6 postinfection. Data are expressed as HIV (A) and SIV (B) RT activity in morphine-treated cells (percentage of control) to those in untreated cells, morphine-treated cells plus naltrexone versus morphine only. The results represent the mean ± SD of three experiments using cells from three different donors. Statistical analysis was performed using one-way analysis of variance, and significance is shown with * P<0.05 (morphine vs control or morphine vs morphine + naltrexone).