Table 2. Number of semi-quantitative analytes significantly altered in patients diagnosed with Alzheimer's disease obtained from t-test analysis in dependency of gender and significance threshold p (in grey: number of significant changes equal or below expected false-positive rate).

significance threshold p	Females	AD MMSE>22 vs. controls	AD MMSE 14–22 vs. controls	AD all vs. controls
<0.05	All Centers	33	23	29
	Core Centers only	20	15	17
<0.01	All Centers	9	4	13
	Core Centers only	3	0	3