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. 2012 Feb 16;7(2):e31464. doi: 10.1371/journal.pone.0031464

Figure 4. Neutralization of HIV-1 SF162 by sera from rabbits co-immunized with HIV-1 Env-E2 VLPs and Env(gp160) plasmid DNA following different immunization regimens.

Figure 4

(A) Neutralizing activity in the sera of rabbits from Groups 1 (blue), 2 (red) and 3–5 (green) against HIV-1 SF162. Final titers were calculated as the reciprocal of the dilution of serum necessary to inhibit infection by 50% and informed as the mean titers (+/− S.D.) for each group. The dotted line represents the limit of detection of the assay (1∶16). (B) Comparison of the NAb area under the curve (AUC) among the above mentioned groups. Asterisks denote statistical significance: ** P<0.01.