Table 6. Top canonical pathways affected by up-regulated genes/isoforms after thrombin treatment of HMVEC cells.

Up regulated genes
Canonical Pathway	p value	Genes
Role of IL-17A in Psoriasis	0.000	23%
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F	0.000	22%
TREM1 Signaling	0.000	19%
Role of Cytokines in Mediating Communication between Immune Cells	0.000	13%
Role of IL-17F in Allergic Inflammatory Airway Diseases	0.000	13%

Top canonical pathways significantly up-regulated by thrombin treatment as determined by Ingenuity Pathway Analysis. Pathways with a p-value less than 0.05 defined as significant.