Table 7. Top canonical pathways affected by down-regulated genes/isoforms after thrombin treatment of HMVEC cells.

Down regulated genes
Canonical Pathway	p value	Genes
DNA Double-Strand Break Repair by Homologous Recombination	0.000	64%
DNA Double-Strand Break Repair by Non-Homologous End Joining	0.000	57%
Role of BRCA1 in DNA Damage Response	0.000	36%
Aldosterone Signaling in Epithelial Cells	0.001	19%
Role of CHK Proteins in Cell Cycle Checkpoint Control	0.004	29%

Top canonical pathways significantly down-regulated by thrombin treatment as determined by Ingenuity Pathway Analysis. Pathways with a p-value less than 0.05 defined as significant.