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. 2012 Feb 16;7(2):e32267. doi: 10.1371/journal.pone.0032267

Figure 6. BITC administration increase PUMA expression in vivo in MDA-MB-231 xenografts.

Figure 6

Immunohistochemical analysis for (A) PUMA and (C) Bcl-xL in MDA-MB-231 tumor sections from control and BITC-treated mice (7). Magnification- 200×; scale bar- 40 µm. Immunoblotting for (B) PUMA and (D) Bcl-xL using tumor supernatants from control and BITC treatment groups. Lower panels in B and D represent densitometric quantitation (arbitrary units). Statistical significance was determined by Student's t-test (n = 5 for control and n = 3 for BITC treatment group).