Table 2.
Data From Microarray Analysisa
Variable | Fold Changes |
−Log10 (p Value) | Variable | Fold Changes |
−Log10 (p Value) |
---|---|---|---|---|---|
PLA2-G1B | 0.20025 | 0.51986 | PLC-β1 | −0.14719 | 0.35611 |
PLA2-G2A | −0.38263 | 0.85158 | PLC-β2 | 0.108125 | 0.71506 |
PLA2-G4A | 0.05025 | 0.38109 | PLC-β3 | −0.0045 | 0.5079 |
PLA2-G4C | 0.150875 | 0.41136 | PLC-β4 | 0.15325 | 0.47148 |
PLA2-G5 | −0.23550 | 0.26525 | PLC-γ1 | 0.036625 | 0.46310 |
PLA2-G6 | −0.00167 | 0.7964 | PLC-γ2 | −0.05863 | 0.41421 |
PLA2-G7 | 0.092375 | 0.4245 | PLC-δ1 | −0.12919 | 0.601 |
PLA2-G10 | 0.032313 | 0.7037 | PLC-ε1 | −0.2055 | 0.38971 |
PLA2-G15 | 0.218188 | 0.63171 | PLC-η1 | 0.05125 | 0.38601 |
PLA2-G16 | 0.051313 | 0.29672 | PLC-η2 | 0.046625 | 0.40614 |
TXA-2 receptor | −0.02581 | 0.59576 | TXA-2 synthase | 0.066 | 0.72305 |
MAPK-1 | 0.578313 | 0.88625 | Rho-GEF-1 | −0.03756 | 0.514944 |
MAPK-3 | −0.41356 | 0.87362 | Rho-GEF-2 | 0.215 | 0.531000 |
MAPK-4 | 0.057438 | 0.50662 | Rho-GEF-4 | −0.0745 | 0.645063 |
MAPK-6 | 0.452125 | 0.81766 | Rho-GEF-5 | −0.20275 | 0.554031 |
MAPK-7 | 0.1885 | 0.55187 | Rho-GEF-7 | 0.190938 | 0.895394 |
MAPK-8 | −0.03033 | 0.46150 | Rho-GEF-10 | 0.087813 | 0.359363 |
MAPK-9 | 0.4345 | 0.75439 | Rho-GEF-11 | 0.228375 | 0.710306 |
MAPK-10 | 0.176938 | 0.45802 | Rho-GEF-12 | 0.042 | 0.545938 |
MAPK-11 | 0.058563 | 0.38492 | Rho-GEF-15 | 0.0495 | 0.45661 |
MAPK-12 | −0.0325 | 0.45474 | Rho-GEF-16 | −0.02125 | 0.63001 |
MAPK-13 | −0.07294 | 0.44960 | Rho-GEF-17 | 0.063563 | 0.40668 |
MAPK-14 | 0.3535 | 0.73609 | Rho-GEF-18 | −0.5015 | 0.94140 |
MTOR | 0.33968 | 0.67460 | Rho-A | 0.183625 | 0.44555 |
PKC-α | 0.159375 | 0.44953 | PLD-1, PS | −0.0155 | 0.460233 |
PKC-β | 0.130625 | 0.45263 | PLD-2 | 0.01825 | 0.442563 |
PKC-γ | 0.0925 | 0.44668 | PLD-3 | 0.635625 | 0.887557 |
GRK-1 | 0.50405 | 0.148125 | GSK-β | 0.253125 | 0.456617 |
GRK-4 | 0.55180 | −0.05544 | CaM-1-PK-δ | −0.09713 | 0.630019 |
GRK-5 | 0.68997 | 0.074125 | CaM-3-PK-δ | 0.142563 | 0.406688 |
GRK-6 | 0.57186 | −0.13606 | Caldesmon 1 | 0.784933 | 0.941400 |
Microarray analysis showed no significant changes in the gene expression of TXA-2 receptors, TXA-2 synthase, PLC-γ1, or PLC-β3 after cardioplegic ischemia and reperfusion.
CaM-PK = calmodulin phosphorylase kinase; GRK = G protein–coupled receptor kinase; GSK = glycogen synthase kinase; MAPK = mitogen-activated protein kinase; MTOR = mammalian target of rapamycin; PKC = protein kinase C; PLA = phospholipase A; PLC = phospholipase C; PLD = phospholipase D; Rho-A = Ras homolog gene family, member A; Rho-GEF = Rho guanine nucleotide exchangefactor; TXA = thromboxane A.