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. 2012 Feb 15;20(4):1607–1615. doi: 10.1016/j.bmc.2011.12.018

Scheme 3.

Scheme 3

Preparation of triazole quinol analogues containing a benzamidine or a melamine moiety. Reagents and conditions: (a) NaNO2, NaN3, H2SO4, H2O, 0 °C, 56%; (b) 1, CuI, lutidine, MeCN, 4%; (c) NaN3, Et3N, DMF/H2O, 115 °C, 31%; (d) 1, CuI, lutidine, MeCN, 3%.