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. 2012 Feb 17;2:273. doi: 10.1038/srep00273

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Copyright © 2012, Macmillan Publishers Limited. All rights reserved

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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(A) WT and Tet2-mutant FL cells (Ly5.2) were transplanted into lethally irradiated recipients (Ly5.1), and percentages of donor chimerism in recipient's PB were analyzed by flow cytometry at the indicated time points after transplantation. Serial transplantations were performed as described in Methods. The data represents the mean ± S.D. (1^st transplantation; Tet2^+/+: n = 4, Tet2^+/gt and Tet2^gt/gt: n = 5, 2^nd and 3^rd transplantation; Tet2^+/gt: n = 4, Tet2^+/+ and Tet2^gt/gt: n = 5). (B) (Upper panel) Flow cytometric analysis of donor derived HSC fraction (CD34⁻LSK cells) within Lin⁻ fraction of BM mononuclear cells in mice receiving the first transplants. Representative FACS pictures are shown. (Lower panel) Percentages of donor derived CD34⁻LSK cells within Lin⁻ fraction of BM mononuclear cells in mice receiving the first transplants. The data represents mean ± S.D. (n = 3 for each recipient).