Figure 4. Differentiation of Tet2-mutant FL cells in transplanted recipient mice.

Fractions of mature granulocytes (Gr-1⁺CD11b⁺), monocytes (F4/80⁺CD11b⁺) and lymphocytes (B220⁺ or CD3⁺) in mice transplanted with WT or Tet2-mutant FL cells were analyzed at 12 weeks after the 1^st or 2^nd transplantation by flow cytometry. The data represents the mean ± S.D. (1^st transplantation; Tet2^+/+ recipient: n = 4, Tet2^+/gt and Tet2^gt/gt recipient : n = 5, 2^nd transplantation; Tet2^+/gt recipient : n = 4, Tet2^+/+ and Tet2^gt/gt recipient : n = 5). (A) Representative FACS pictures are shown. (B, C, D) Percentages of granulocytes (B), monocytes (C), and B or T cells (D) are shown on the graphs. The data are mean ± S.D.