Figure 2.

Structural organization of BACE1 (active isoform of 501 amino acids). Schematic diagram of the domain structure, post-translational modifications and interaction motifs of BACE1.The active sites motifs DTGS and DSGT at position 92–95 and 289–292 are marked as stars, the critical aspartic residues are highlighted in red. The DISLL motif at the cytosolic domain is recognized by GGA proteins and serves as an endosomal targeting signal. Glycosylation sites are depicted as sugar “trees,” palmitoylation sites as fatty acid chains. S–S, disulfide bond (connecting amino acids 216–420, 278–443, 330–380); P, phosphorylation site; Ub, ubiquitination site.