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Schematic model of PTEN-mediated control of c-FLIPS ubiquitination and TRAIL sensitivity. (A). USP8 interacts with AIP4 which can ubiquitinate c-FLIPS leading to its degradation; (B). Increase in pAkt decreases USP8 expression, turns off the USP8/AIP4 ubiquitin switch, resulting in c-FLIPS accumulation. Modified from Panner et al. [114].
