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. Author manuscript; available in PMC: 2013 Jan 24.
Published in final edited form as: Circulation. 2012 Jan 24;125(3):539–549. doi: 10.1161/CIRCULATIONAHA.111.033563

Table.

Definitions of cardiac alternans

  • Sub-cellular spatially concordant [Ca2+]i alternans - oscillation of calcium concentration within the myocyte such that [Ca2+] within all sub-cellular areas oscillates in-phase (i.e. all sub-cellular regions demonstrate high or low [Ca2+]).

  • Sub-cellular spatially discordant [Ca2+]i alternans - oscillation of calcium concentration within the myocyte such that [Ca2+] within adjacent sub-cellular areas oscillates out-of-phase (i.e. some sub-cellular regions demonstrate high [Ca2+] and adjacent sub-cellular regions demonstrate low [Ca2+]).

  • Cellular concordant [Ca2+]i and AP alternans - oscillation of intracellular calcium concentration and AP voltage such that these signals are in-phase (i.e. a large [Ca2+]i corresponds to a long APD and vice versa).

  • Cellular discordant [Ca2+]i and AP alternans - oscillation of intracellular calcium concentration and AP voltage such that these signals are out-of-phase (i.e. a large [Ca2+]i corresponds to a short APD and vice versa).

  • Tissue/whole heart spatially concordant APD alternans – oscillation of action potential duration such that adjacent areas of the heart are in-phase (i.e. adjacent regions demonstrate either long or short APDs).

  • Tissue/whole heart spatially discordant APD alternans - oscillation of action potential duration such that adjacent areas of the heart are out-of-phase (i.e. one area of the heart demonstrates long APDs while an adjacent area demonstrates short APDs).