Table 3.
Cross-section optical coherence tomography segmentation analysis
| Multiple sclerosis |
Neuromyelitis optica |
HC matched to MS cohort | HC matched to NMO cohort | |||||
|---|---|---|---|---|---|---|---|---|
| ON eyes | Non-ON eyes | P-value | ON eyes | Non-ON eyes | P-value | |||
| Number of eyes | n = 73 | n = 123 | n = 17 | n = 23 | n = 100 | n = 44 | ||
| ARFNLT (µm) (SD) | 78.7 (11.7) | 84.9 (12.2) | <0.001 | 68.5 (13.9) | 87.6 (16.4) | <0.001 | 93.4 (10.4) | 93.2 (9.5) |
| AMT (µm) (SD) | 263.5 (15.2) | 272.2 (14.9) | <0.001 | 248.5 (13.2) | 265.0 (16.0) | <0.001 | 282.7 (14.7) | 285.3 (14.9) |
| AT GCL + IPL (µm) (SD) | 65.6 (10.4) | 73.2 (9.3) | <0.001 | 56.4 (9.7) | 71.6 (12.1) | <0.001 | 81.9 (6.5) | 81.9 (6.8) |
| AT RNFL + GCL + IPL (µm) (SD) | 91.6 (15.5) | 102.9 (13.0) | <0.001 | 75.8 (15.7) | 100.0 (16.6) | <0.001 | 115.3 (8.5) | 114.8 (10.0) |
| AT INL + OPL (µm) (SD) | 65.3 (4.0) | 65.1 (5.0) | 0.82 | 65.0 (5.5) | 61.6 (3.2) | 0.02 | 65.1 (4.8) | 65.5 (4.1) |
| AT ONL + PRL (µm) (SD) | 119.4 (8.6) | 118.9 (6.9) | 0.58 | 120.3 (7.8) | 115.7 (5.2) | 0.03 | 121.4 (10.0) | 121.3 (7.8) |
| Letters read correctly at | ||||||||
| 100% (SD)a | 58.2 (11.9) | 59.2 (7.0) | 0.51 | 28.1 (25.3) | 48.2 (17.1) | 0.001 | 61.7 (7.3) | 61.3 (7.5) |
| 2.5% (SD)a | 27.4 (13.3) | 27.9 (11.3) | 0.82 | 6 (8.1) | 16.2 (16.0) | 0.004 | 32.7 (8.7) | 32.3 (10.3) |
| 1.25% (SD)a | 13.1 (11.5) | 13.5 (11.2) | 0.81 | 1.7 (2.7) | 8.1 (9.9) | 0.004 | 20.6 (9.6) | 17.7 (9.0) |
The P-values displayed compare the optic neuritis eyes to the non-optic neuritis eyes for each disease.
a MS ON eyes: n = 67, MS non-ON eyes n = 121, NMO ON eyes: n = 15, NMO non-ON eyes n = 16, HC matched to MS eyes n = 87, HC matched to NMO eyes n = 39.
AMT = average macular thickness; ARNFLT = average peripapillary retinal nerve fiber layer thickness; AT = average thickness; GCL = ganglion cell layer; HC = healthy control; IPL = inner plexiform layer; INL = inner nuclear layer; MS = multiple sclerosis; NMO = neuromyelitis optica; ON = optic neuritis; ONL = outer nuclear layer; OPL = outer plexiform layer; PRL = photoreceptor segments layer; SD = standard deviation.