. Author manuscript; available in PMC: 2012 Apr 28.

Published in final edited form as: J Med Chem. 2011 Apr 5;54(8):3037–3050. doi: 10.1021/jm2001376

Table 2.

PK Parameters of the Compounds 21b,e–j in Mice by Oral Cassette Dosing at 5 mg/kg (n =1) and in Rats by Oral Administration at 1 mg/kg (n=4).

species	Inhibitors	T_max (h)	C_max (nM)	AUC (nM*h)	t_1/2 (h)
Mouse	21h	0.8	190	375	2.4
	21i	0.8	260	980	2.6
	21j	0.8	290	1335	2.4
	21e	0.5	100	125	3.1
	21b	0.5	19	35	1.0
	21g	0.5	42	100	3.5
	21f	0.5	20	22	1.7

Rat	21i	1.5 ± 0.6	415 ± 139	2764 ± 804	13 ± 4
	21j	1.0 ± 0.7	180 ± 71	1230 ± 521	12 ± 6