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. Author manuscript; available in PMC: 2013 Feb 9.
Published in final edited form as: Eur J Neurosci. 2012 Feb 9;35(3-4):614–622. doi: 10.1111/j.1460-9568.2012.07991.x

Figure 2.

Figure 2

Partial reversal of PEPA-induced suppression of cue-induced cocaine-seeking by dopaminergic activation of the PL or BLA. A, Active lever presses (mean +/− SEM) during extinction and cue-induced reinstatement for the IL-PL experiments. Intra-IL microinjections of PEPA suppressed cue-induced reinstatement, whereas rats receiving PEPA into the IL and dopamine into the PL showed significant reinstatement. Rats were counterbalanced across IL microinjections. B, Active lever presses (mean +/− SEM) during extinction and cue-induced reinstatement for the IL-BLA experiments. Intra-IL microinjections of PEPA suppressed cue-induced reinstatement, whereas rats receiving PEPA into the IL and dopamine into the PL showed significant reinstatement. For the IL-BLA experiment, intra-BLA microinjections of dopamine alone immediately prior to an extinction session did not significantly affect cocaine-seeking behavior. Rats were counterbalanced across BLA micrionjections. *, p < 0.05 compared to extinction baseline.