Table 2.

Atypical PS/γ-secretase substrate proteins and suggested roles of their PS/γ-secretase-mediated cleavage

Number	Substrate	Function	PS/γ-secretase cleavage product	Localization of cleavage product	Suggested function of PS/γ-secretase cleavage	References
1.	GluR3	Glutamate receptor subunit; synaptic transmission	GluR3sβ	n.d.	n.d.	[116]
2.	GnT-V	Glucosaminyltransferase; tumor metastasis, angiogenesis, endothelial cell proliferation	Soluble GnT-V	CM	Regulation of secretion of soluble GnT-V; tumor metastasis, angiogenesis?	[115]

Abbreviations: CM, conditioned medium; GluR3, glutamate receptor 3; n.d., not determined.