FIGURE 6.

Retinal function in Abca4^−/−Rdh8^−/− mice is substantially preserved by several different treatments. Scotopic ERGs were recorded and both a-waves (top) and b-waves (bottom) were plotted to evaluate retinal function in Abca4^−/−Rdh8^−/− mice 7 days after they were pretreated with the indicated compounds. Compared with WT mice exposed to bright light (Light_WT) and Abca4^−/−Rdh8^−/− mice without light exposure (No light), light exposure at 10,000 lux for 30 min significantly impaired retinal function as indicated by decreased a-wave and b-wave amplitudes in mice treated with DMSO vehicle control (Light_DMSO). Compounds showing a protective effect against this light-induced retinopathy included ketanserin, ritanserin, 4-DAMP, U-73122, 2-APB, APO, and DPI.