FIGURE 7.

Light-induced retinal degeneration in BALB/c mice. Twelve-week-old BALB/c mice were dark-adapted followed by indicated pharmacological treatments via intraperitoneal injection 1 h prior to their exposure to white light at 10,000 lux for 2 h. All experimental evaluations were carried out 7 days later. Controls either without light exposure (No light) or with DMSO vehicle treatment followed by light exposure (Light_DMSO) were included for all analyses. A, retinal thin sections examined under light microscopy (63×) after toluidine blue staining. Scale bar, 20 μm on all panels. B, retinal function assessed by scotopic ERG in BALB/c mice 7 days after the indicated pretreatments.