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Model of conserved bile acid-like signaling pathways in nematodes and mammals. Bile acid-like signaling pathways in mammals and nematodes are compared and illustrated. Free-living nematodes (e.g. C. elegans) produce their own DAF-12 ligands to regulate the reproductive development. Parasitic nematode (e.g. hookworms) might use the host bile acid(-like) metabolites to activate their DAF-12 to regulate the reproductive development.
