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. 2011 Dec 20;287(7):5091–5101. doi: 10.1074/jbc.M111.278994

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Telomere shortening in Brca2-depleted MEFs. Brca2^f11/f11 MEFs were analyzed for their overall telomere length after infection with Ad-GFP or Ad-Cre by measuring fluorescent telomere signals with Q-FISH (TFL-Telo program). A, telomeres shorten in Brca2-deficient MEFs in a passage-dependent manner. Ad-Cre-infected Brca2^f11/f11 MEFs display a significant degree of telomere shortening after Cre expression, compared with control (Ad-GFP). x axis, relative fluorescence units; y axis, number of chromosomes. N, number of chromosomes analyzed. Mean value of relative fluorescence units are also indicated. Data were analyzed using SPSS software. B, relative intensity of the telomere signals in Ad-GFP- or Ad-Cre-infected MEFs. Chromosomes from at least 60 different cells were analyzed. TFU, telomere fluorescence unit. Bars represent the relative fluorescence intensity over control MEFs (Ad-GFP), measured at day 7 post-viral infection in Brca2^f11/f11 MEFs. Error bar represents the mean ± S.D.