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. 2011 Dec 22;287(7):4740–4751. doi: 10.1074/jbc.M111.321141

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Structures of RanGAP1-SUMO/UBC9/RanBP2 complexes. Schematics represent complexes containing RanGAP1-SUMO1/UBC9/IR1 (A; PDB 1Z5S), RanGAP1-SUMO2/UBC9/IR1 (B), RanGAP1-SUMO1/UBC9/IR1_SIM-IR2_II-IR1_III–V (C), and RanGAP1-SUMO2/UBC9/IR1_SIM-IR2_II-IR1_III–V (D). SUMO1, SUMO2, RanGAP1, UBC9, IR1, and IR2 motif II are displayed in yellow, green, light pink, blue, magenta, and pink, respectively. Lys⁵²⁴ of RanGAP1 and the SUMO C-terminal glycine (Gly⁹⁷ for SUMO1, Gly⁹³ for SUMO2) and are in stick representation. A rotated view of each complex is shown below each panel to highlight the position of SUMO and the IR1 SIM with respect to UBC9. Structural figures were generated with PyMOL (38).