Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of insulin and PMA on various phosphorylation sites on IRS1
| Residue | Treatment with insulin | Treatment with PMA |
|---|---|---|
| Ser-307 | No change | No change |
| Ser-612 | No change | 1.9 ± 0.3-fold increasea (p < 0.05) |
| Tyr-608 | 2.6 ± 0.3-fold increase (p < 0.05) | No effect on insulin-stimulated increase |
| Tyr-891 | No change | No change |
a Reversal of phosphorylation with PD98059 did not affect the inhibitory effect of PMA as assessed by PI3K activity and Akt phosphorylation.
