FIGURE 4.

RGS6 modulates GABA_BR signaling. WT and RGS6^−/− mice (n = 9 each) were tested at fixed speed (A) and during acceleration from 5 rpm (B) on the rotarod after administration of baclofen (10 mg/kg), a GABA_BR agonist. Administration of blood-brain barrier permeant GABA_BR antagonist SCH-50911 (30 mg/kg) partially rescued ataxic phenotype of RGS6^−/− mice on rotarod at fixed speed (C) and completely rescued the phenotype during acceleration from 5 rpm (D). Data are presented as mean ± S.E. *, p < 0.05; **, p < 0.01 versus WT.