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. 2011 Dec 16;287(7):4972–4981. doi: 10.1074/jbc.M111.297218

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Loss of RGS6 potentiates GABA_BR-GIRK signaling in isolated CGNs. A, representative baclofen (200 nm)-induced whole cell GIRK current recordings in isolated CGNs from WT and RGS6^−/− mice. GIRK currents from RGS6^−/− mice exhibit (B) a significant delay in the half-maximal deactivation but not activation time constant (τ_1/2) without any significant changes in the extent of desensitization (C) and current density (D) (WT, n = 8; RGS6^−/−, n = 10). Data are presented as mean ±S.E.; *, p < 0.05 versus WT.