FIGURE 8.

Higher expression of proangiogenic genes in 11βHSD1^−/− in obesity. A, adipose mRNA levels of a panel of potent angiogenic factors, corrected for β-actin (n = 8). The bars indicate the following: SVF from HF control at 21% oxygen (white bars), 1% oxygen (diagonal hatched bars), HF 11βHSD1^−/− 21% oxygen (black bars) and 1% oxygen (vertical hatched bars). Cells were kept in 1% oxygen for 6 h. Data are presented as means ± S.E. SVF was prepared from four individual mice. AU, arbitrary units. B and C, mRNA levels of VEGF-A (B) and ANGPTL4 (C). *, p < 0.05, **, p < 0.01, and ***, p < 0.001.