TABLE 1.

Similar body weight and adipose mass gain in 11βHSD1^−/− mice after HF feeding

11βHSD1^−/− and control (C57BL/6) mice gained similar weight (n = 6). Body fat distribution and subcutaneous and mesenteric fat deposition were similar after 12 weeks on HF diet. * indicates significant differences between control chow and high fat diet in both genotypes. CD, chow-fed; HFD, high fat diet-fed; BW, body weight.

	C57BL/6 CD	C57BL/6 HFD	11βHSD1−/− HFD	p values
Terminal BW (g)	38.8 ± 3.2*	49.2 ± 1.7	53 ± 1.1	<0.0001
BW gain (g)	5.9 ± 0.3*	16.1 ± 1.2	17.1 ± 1.2	<0.0001
scAT (g)	0.4 ± 0.03*	1.0 ± 0.06	1.2 ± 0.09	<0.0001
mesAT (g)	0.7 ± 0.06*	1.5 ± 0.1	1.6 ± 0.1	<0.0001
scAT/BW ratio	0.010 ± 0.0006*	0.020 ± 0.001	0.022 ± 0.001	<0.0001
mesAT/BW ratio	0.018 ± 0.0009*	0.030 ± 0.001	0.031 ± 0.001	0.0006