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. 2011 Nov 10;287(6):4014–4022. doi: 10.1074/jbc.M111.312264

FIGURE 4.

FIGURE 4.

Paxilline inhibits the proliferation of RA-FLS without inducing toxicity. A, dose-dependent inhibition of RA-FLS proliferation by paxilline. Cells were left unstimulated (white) or were stimulated with 20 ng/ml LPS (light gray), 20 μg/ml poly(I·C) (dark gray), or 1 μg/ml PGN (black) for 72 h. Data are from five independent experiments with cells from five different donors. B, dose-dependent inhibition of RA-FLS proliferation by TEA. Data are from four independent experiments with cells from four different donors. C, dose-dependent toxicity of staurosporine (gray) and paxilline (black) over a 48-h incubation with RA-FLS. Data are from four independent experiments with cells from four different donors. **, p ≤ 0.01; ***, p ≤ 0.001.