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Knockdown of VLDLR and apoER2 reduces reelin-induced PI3K phosphorylation and ABCA1 protein expression. A and B, mouse macrophages were transfected with siRNA against apoER2 or VLDLR or control (Ctrl) siRNA. The transfected cells were then incubated with 2 μg/ml reelin or culture medium alone for 1 h. The level of phosphorylated PI3K (p-PI3K) and ABCA1 protein was determined by Western blot analysis and quantitated relative to β-actin.
