FIGURE 7.
HUCB cells reduce damage to striatal white matter. Photomicrographs depict ipsilateral striatal area of animals subjected to Sham (A), MCAO (B), and MCAO + HUCB cells (C). Antibodies generated against MBP were used to evaluate striatal white matter damage in rats subjected to MCAO and euthanized 72 h following surgery. Immunoreactivity for MBP (D) increased in the striatum after MCAO (B), whereas systemic administration of HUCB cells 48 h following MCAO blocked this increase in MBP immunoreactivity (C, n = 3; *, p < 0.05). Sham-operated controls were not statistically different from groups treated with HUCB cells (p > 0.05). Arrows point to white matter in the striatum. Scale bars = 100 μm; inset images, 50 μm.