FIGURE 4.

IFG stabilized GCase protein in serum. The hGCase is expressed in and secreted from hG/4L/PS-NA mouse livers. A, in IFG-treated mice (30 mg/kg/day for 4 weeks) hGCase activities secreted into the serum were significantly increased compared with untreated mice. B, immunoblot of GCase in serum determined by anti-hGCase antibody and quantitated relative to known amounts of imiglucerase as standard. Human GCase protein in the serum from IFG-treated mice was significantly increased compared with the untreated mice. Data were analyzed by Student's t test (duplicate assays). **, p < 0.01; ***, p < 0.001. The results and error bars represent the mean ± S.E. (n = 3 mice).