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Schematic representation of cellular effects of miR-21-mediated down-regulation of DOCK4, -5, or -7 in vascular smooth muscle cells. BMP4 induces miR-21 and inhibits migration and increases contractility of vSMCs. miR-21 targets DOCK4, -5, and -7 to control vSMC migration by modulating the activity of Rac1, whereas DOCK4 and -5 modulate contractility of vSMC via a Rac1-independent mechanism.
