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. 2011 Dec 5;287(6):4099–4106. doi: 10.1074/jbc.M111.310789

FIGURE 4.

FIGURE 4.

Effect of BMPER and TWSG1 on BMP2- and BMP6-dependent hepcidin promoter activity in HepG2 cells. A, luciferase reporter assays showing the effect of increasing doses of BMPER (1–5000 ng/ml) on BMP6 (25 ng/ml)- and BMP2 (25 ng/ml)-dependent hepcidin promoter activity (*, p < 0.03; δ, p < 0.01 compared with control levels, multiple ANOVA with Tukey's post hoc analysis). B, effect of BMPER (1–1000 ng/ml) and TWSG1 (1–1000 ng/ml) alone or in combination on BMP2 (25 ng/ml)-dependent hepcidin promoter activity (*, p < 0.05; δ, p < 0.01; multiple ANOVA with Tukey's post hoc analysis). Luciferase assays shown are means ± S.D. derived from a single experiment with three biological replicates, and the experiment shown is representative of three similar experiments.