Sequence comparison of BMPER, Cv-2, and Hjv.
Upper panel, BMPER, Hjv, and Cv-2 share a common von Willebrand type D domain (vWD), a fully conserved acid-sensitive autocatalytic cleavage site, and a C-terminal furin cleavage site. BMPER and Cv-2 contain five N-terminal cysteine-rich regions (CR1–5), which are involved in binding BMPs; these domains are absent in Hjv. Lower panel, multiple alignment (Clustal) of mouse, human, and zebrafish BMPER and Hjv sequences showing a fully conserved acid-sensitive autocatalytic cleavage site. TI = trypsin inhibitor domain.