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. Author manuscript; available in PMC: 2012 Feb 17.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2007;72:527–541. doi: 10.1101/sqb.2007.72.037

Figure 5.

Figure 5

Constant light (LL) produces behavioral “splitting” (A) in which the animal’s single daily bout of activity separates into two components, and the two component free-run until they become stably coupled 12 hours apart. LL also induces antiphase oscillation within each side of the SCN (B). PER1 is not uniform on either side of the SCN, but it is high in the left shell and low in the left core. In contrast, PER1 is low in the right shell and high in the right core. The asymmetry of the bilateral core and shell SCN was quantified in split animals killed every 3 hours (C). The y axis is in log scale. Error bars indicate S.E. (Modified, with permission, from Yan et al. 2005 [Society for Neuroscience].)