Table 1. Top 5 networks in THP-1 cells after 8 h treatment with 10% CSE.

Associated Network functions	Molecules in Network	Focus Molecules	Score
Cell Death, Lipid Metabolism, Small Molecule Biochemistry	AKAP7, CDKN1A, CREB1, CRHR1, CYP1B1, EIF2S1, ERK1/2, FSH, HMOX1, Ifn gamma, IgG, IL5, IL8, IRF8, Jnk, LITAF, LPA, NFkB (complex), NINJ1, P2RY2, PIM1, PMAIP1, PPP1R15A, RNA polymerase II, RND3, SAT1, SERPINB2, SERPINB8, SERPINB10, SOAT1, SQSTM1, TDRD7, TNF, TNFAIP2, TNFAIP3	21	37
Organismal Injury and Abnormalities, Respiratory Disease, Cell Death	ADRB2, ANXA1, BIK, CCL18, CTSC, CYSLTR1, DUSP5, DUSP10, G0S2, GBP1 (includes EG:2633), GCLM, GPR109B, IFNGR1, IL5, IL13, IRAK3, KRT15, LGALS3, LPL, LTB, MGST1, MMD, NID1, OSGIN1, RFTN1, RPS6KA2, RRM2, SLC3A2, SP1, SP3, TNF, TP53, TP53I3, TXNRD1, UBQLN2	11	15
Cellular Assembly and Organisation, Amino Acid Metabolism, Post-Translational modification	GABARAPL1, HDAC6	1	2
Molecular Transport, Nucleic Acid Metaolism, Small Molecule Biochemistry	NME1, SERTAD1	1	2
Drug Metabolism, Cell Death, Amino Acid Metabolism	MIR122 (includes EG:406906), SLC7A11	1	2

THP-1 monocytes were treated for 8 hours with RPMI-1640 control medium (n = 6) or 10% CSE-conditioned medium (n = 6). Genes that were significantly modified by ≥1.5-fold, as assessed using student's t-test followed by Benjamini-Hochberg FDR correction, were imported into Ingenuity Pathway Analysis software. The table shows the top 5 networks identified from genes differentially expressed by ≥1.5-fold in THP-1 monocytes treated with 10% CSE.