. 2012 Feb 17;7(2):e30120. doi: 10.1371/journal.pone.0030120

Table 7. Genes observed to be differentially expressed by ≥2-fold in THP-1 monocytes in response to cigarette smoke were also differentially expressed in previous studies examining the effects of cigarette smoke on various cell types in vivo and in vitro.

Symbol	Entrez ID	Reg	FC	Description	Reference
HMOX1 ¹ ^, ² ^, ³	3162	up	22.6	heme oxygenase 1	[31], [36], [58], [59], [60], [61]
MSC	9242	up	5.8	musculin (activated B-cell factor-1)
GCLM ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵	2730	up	4.8	glutamate-cysteine ligase, modifier subunit	[27], [30], [32], [33], [36], [37], [42]
NQO1	1728	up	3.8	NAD(P)H quinone oxioreductase 1	[31], [32], [33], [36], [53], [62]
RIT1	6016	up	3.1	Ras-like without CAAX 1
SRNX1 ¹	140809	up	2.3	sulfiredoxin 1	[36], [63]
CYP1B1 ¹ ^, ² ^, ⁵	1545	up	2.3	cytochrome P450, family 1, subfamily B, polypeptide 1	[27], [32], [35], [36], [43], [52], [64], [65], [66]
FTHL12	2504	up	2.9	ferritin, heavy polypeptide-like 12
ME1 ¹ ^, ²	4199	up	3.4	NADP(+)-dependent malic enzyme 1	[32], [40]
PANX2	56666	up	2.7	pannexin 2
HMFN0839 ¹	84803	up	2.5	Glycerol -3-phosphate acetyltransferase 9	[53]
IL8 ² ^, ³ ^, ⁴ ^, ⁷	3576	up	2.7	interleukin 8	[13], [14], [31], [67]
FLJ20489	55652	up	2.7	Solute carrier family 48 (heme transporter), member 1
FTHL7	2500	up	2.5	ferritin, heavy polypeptide-like 7
TXNRD1 ¹ ^, ² ^, ⁵	7296	up	2.6	thioredoxin reductase 1 (transcript variant 1)	[27], [30], [32], [36], [52], [65]
SLC7A11 ⁵	23657	up	2.0	solute carrier family 7	[27]
PIR ¹	8544	up	2.7	pirin (transcript variant 2)	[32], [35], [68]
C16orf28	65259	up	2.4	chromosome 16 open reading frame 28 mRNA
FTHL3	2498	up	2.0	ferritin, heavy polypeptide-like 3
SQSTM1	8878	up	2.5	sequestosome 1
TXNRD1 ¹ ^, ² ^, ⁵	7296	up	2.3	thioredoxin reductase 1 (transcript variant 4)	[27], [30], [32], [36], [52], [65]
GABARAPL1 ²	23710	up	2.7	GABA(A) receptor-associated protein like 1	[69]
PIR ¹	8544	up	2.7	pirin (transcript variant 1)	[32], [35], [68]
TNF ² ^, ³ ^, ⁶ ^, ⁷	7124	up	2.1	tumor necrosis factor	[13], [15], [23], [24]
PGD ¹ ^, ⁴	5226	up	2.5	phosphogluconate dehydrogenas	[29], [30], [32]
SERPINB2	5055	down/up	3.8	Plasminogen activator inhibitor	[25], [26], [27]
GPR18	2841	down	2.2	N-arachidonyl glycine receptor
LOC389816	389816	down	2.3	Leucine-rich repeat-containing protein 26
LOC389816*	389816	down	2.2	Leucine-rich repeat-containing protein 26

Observed in airway epithelial cells,

Observed in lung tissue,

Observed in monocytes,

⁴

Observed in macrophages,

⁵

Observed in oral leukoplakia,

⁶

Observed in peripheral blood mononuclear cells (PBMCs),

⁷

Observed in bronchioalveolar lavage (BAL), The symbol LOC3898186* is a predicted cDNA sequence similar to LOC3898186.