Table 3. Analysis of genes dysregulated by over-expression, or knock-down, in resting EOC 13.31 cells using either miR-146a mimics or anti-miRs.
Symbol | Entrez Gene Name |
ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
CACNB2 | calcium channel, voltage-dependent, beta 2 subunit |
CASK | calcium/calmodulin-dependent serine protein kinase |
CDC42ER2 | CDC42 effector protein (Rho GTPase binding) 2 |
CDK7 | cyclin-dependent kinase 7 |
CHRNA1 | acetylcholine receptor subunit alpha-1-A |
CPSF2 | cleavage and polyadenylation specific factor 2 |
CYP2B6 | E74-like factor 1 (ets domain transcription factor) |
DNAH1 | dynein, axonemal, heavy chain 1 |
EDEM2 | ER degradation enhancer, mannosidase alpha-like 2 |
EPHA5 | Eph receptor A5 |
GALM | galactose mutarotase (aldose 1-epimerase) |
GATA6 | GATA binding protein 6 |
GFAP | glial fibrillary acidic protein |
GHSR | growth hormone secretagogue receptor |
GLI3 | GLI family zinc finger 3 |
GRIA3 | glutamate receptor, ionotrophic, AMPA |
HIPK2 | homeodomain interacting protein kinase 2 |
HLA-A | major histocompatibility complex, class I, A |
HLA-B | major histocompatibility complex, class I, C |
HLA-C | major histocompatibility complex, class I, C |
IL1B | interleukin-1-beta |
IRF6 | interferon regulatory factor 6 |
KALRN | kalirin, RhoGEF kinase |
KCNJ5 | potassium inwardly-rectifying channel, subfamily J, member 5 |
KDR | kinase insert domain receptor |
KLK10 | kallikrein-related peptidase |
MLLT4 | myeloid/lymphoid or mixed-lineage leukemia |
NRG1 | neuregulin 1 |
NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 |
PARD6B | par-6 (partitioning defective 6) homolog beta |
RRBP1 | ribosome binding protein 1 homolog |
RYR3 | ryanodine receptor 3 |
SMAD3 | SMAD family member 3 |
TMSB4X | thymosin-like 2 |
TUBA1C | tubulin, alpha 1c |
TYRP1 | tyrosinase-related protein 1 |
Genes listed in bold are those that are bioinformatically predicted to be targets of miR-146a using the TargetScan 5.1 program and IPA software.