Table 5. Analysis of genes dysregulated by over-expression, or knock-down, of miR-146a in LPS stimulated EOC 13.31 cells using either miRNA mimics or anti-miRs.
Symbol | Entrez Gene Name |
AMPD3 | adenosine monophosphate deaminase (isoform E) |
ARCN1 | archain 1 |
BCL2L1 | BCL2-like 1 |
CSDE1 | cold shock domain containing E1, RNA-binding |
CSTF2 | cleavage stimulation factor, 3′ pre-RNA, subunit 2, 64 kDa |
DARS | aspartyl-tRNA synthetase |
DHRS9 | dehydrogenase/reductase (SDR family) member 9 |
ELF1 | E74-like factor 1 (ets domain transcription factor) |
FAM107B | family with sequence similarity 107, member B |
FUBP1 | far upstream element (FUSE) binding protein 1 |
HMGCS1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 |
IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 |
IRS1 | insulin receptor substrate 1 |
MED1 | mediator complex subunit 1 |
NOS2 | nitric oxide synthase 2, inducible |
PCTK2 | PCTAIRE protein kinase 2 |
POGK | pogo transposable element with KRAB domain |
PSME4 | proteasome (prosome, macropain) activator subunit 4 |
QKI | quaking homolog, KH domain RNA binding |
QSER1 | glutamine and serine rich 1 |
RAB8B | RAB8B, member RAS oncogene family |
RAI14 | retinoic acid induced 14 |
SEC23A | Sec23 homolog A |
SH3BGRL | SH3 domain binding glutamic acid-rich protein like |
SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
SMAD3 | SMAD family member 3 |
SOX10 | SRY (sex determining region Y)-box 10 |
TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kDa |
TFCP2L1 | transcription factor CP2-like 1 |
UBE2K | ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) |
Genes listed are those that are bioinformatically predicted to be targets of miR-146a using the TargetScan 5.1 program and IPA software.