Figure 5. Schematic summary of the effects of TLE perturbations on Pax6+ and Nkx2.2+ ventral progenitor populations and neuronal fate acquisition.

Pax6 and Nkx2.2 normally repress the expression of each other to establish the pMN/p3 boundary. Overexpression (O.E.) of TLE1 increases the number of Nkx2.2+ progenitor cells and V3 INs at the expense of Pax6+ progenitor cells and somatic MNs. Conversely, exogenous expression of TLE1ΔQ results in an increase in Pax6+ progenitor cells and MNs.