Figure 1. Increased mitosis-phase and centrosomal protein expression in castration-resistant prostate cancer compared with high-grade hormone-sensitive prostate cancer.

Hematoxylin and eosin (H&E)-stained sections showing castration-resistant adenocarcinoma (A), castration-resistant small cell carcinoma (B), and hormone-sensitive high-grade prostate carcinoma (C). Castration-resistant adenocarcinoma immunostained with gamma tubulin (D) and p-histone H3 (G). Castration-resistant small cell carcinoma immunostained with gamma tubulin (E) and p-histone H3 (H). Hormone-sensitive high-grade prostate carcinoma immunostained with gamma tubulin (F) and p-histone H3 (I). Asterisks indicate significantly increased labeling for the mitosis-phase marker p-histone H3 (J) and centrosomal marker gamma-tubulin (K) in castration-resistant prostate carcinoma compared to hormone-sensitive high-grade prostate carcinoma.