Table II.

Average percent difference in the regurgitant orifice area (ROA) when noise is applied to the user-initialized points in semi-automated segmentation. The p-values obtained by single-factor ANOVA indicate a statistically significant difference in the ROA measurements of three categories of MR severity (trace, mild, and moderate to severe).

	Initialization noise
	0.0 mm	0.5 mm	1.0 mm	1.5 mm	2.0 mm
Percent difference in ROA	—	3.7 ± 4.5	8.5 ± 6.0	7.6 ± 7.9	10.5 ± 7.5
p-value	0.002	0.019	0.008	0.001	0.044