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Comparison of base-of-skull case CTV, brainstem, whole brain, optic chiasm, left temporal lobe, and right temporal lobe DVHs for the robustly optimized plan with constraint on the maximum dose in each target voxel [solid lines, Eq. 2b] vs without maximum dose constraint [dashed lines, Eq. 2a]. The constraint makes CTV dose distribution more homogenous but at the cost of reduced normal tissue sparing.
