Table 4. Influence of Substitution Therapy on the Level of Adherence to Treatment.

	Methadone/Buprenorphine Therapy (n = 27)	No Substitution Therapy (n = 67)	P value b
SVR (ITT analysis a), No. (%)	15 (55.55)	50 (74.62)	0.0866
SVR genotype 1 and 4	5 (38.46)	32 (72.72)	0.0442
SVR genotype 2 and 3	10 (71.42)	18 (78.26)	0.7046
Lost of follow-up, No. (%)	7 (25,92)	7 (10.44)	0.1050
Treatment completion rate, No. (%)	27 (100)	64 (95.52) c	0.5546

^a Abbreviation: ITT, intention-to-treat analysis

^b Fisher's exact test

^c In three patients treatment was discontinued