Figure 2. (A) Both, Stat1+/+ and Stat1−/− mammary tumors are heterogenous.
Representative pictures of immunohistochemical characterization of two Stat1+/+ (top panel) and two Stat1−/− mammary tumors (bottom panel). Scale bars: 100 μm. (B) Loss of STAT1 correlates with MIN formation. Representative pictures of immunohistochemical characterization of one low-grade Stat1+/+ (left panel) and one high-grade Stat1−/− MIN (right panel). Stat1+/+ MINs display down-regulation of STAT1 protein, as indicated by the arrow. Scale bars: 100 μm; ERα: estrogen receptor alpha; CK8: cytokeratin 8.